HCID 669172, 화합물 → 4-amino-N-(2-phenylethyl)benzenesulfonamide
반응식
[C:1]1([CH2:7][CH2:8][NH:9][S:10]([C:13]2[CH:18]=[CH:17][C:16]([NH:19]C(=O)C)=[CH:15][CH:14]=2)(=[O:12])=[O:11])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>O1CCOCC1>[C:1]1([CH2:7][CH2:8][NH:9][S:10]([C:13]2[CH:14]=[CH:15][C:16]([NH2:19])=[CH:17][CH:18]=2)(=[O:12])=[O:11])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1참가 물질
3
실험 절차
To a solution of 23 (0.6 g, 1.7 mmol) in dioxane (8 ml) 20% NaOH is added (13 ml) and the mixture is refluxed for 1.5 hours. The solvent is concentrated under reduced pressure and the aqueous phase is added with 20% NaOH to pH=7. The resulting solid is filtered under reduced pressure, washed with water and dried to give compound 24 as white solid (0.43 g, 83% yield).
후처리
- temperaturethe mixture is refluxed for 1.5 hours
- concentrationThe solvent is concentrated under reduced pressure
- additionthe aqueous phase is added with 20% NaOH to pH=7
- filtrationThe resulting solid is filtered under reduced pressure
- washwashed with water
- customdried
출처 및 근거
- ORD 기록
- ord-6be5395a1bea4a3b9bc378ec832df66b
- 출처 데이터셋
- uspto-grants-2009_08
- 특허 번호
- US07579378B2
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