Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl acetoacetate → 1-(2-Hydroxy-cyclohexylmethyl)-2-methyl-5-(2-trifluoromethoxy-phenyl)-1H-pyrrole-3-carboxylic acid cyclohexylamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl acetoacetate | HCID 7757 | — |
| 반응물 | Cyclohexylamine | HCID 7965 | — |
| 반응물 | 2-(Aminomethyl)cyclohexan-1-ol | HCID 533885 | — |
| 반응물 | 2-(Trifluoromethoxy)phenacyl bromide | HCID 2778684 | — |
| 생성물 | 1-(2-Hydroxy-cyclohexylmethyl)-2-methyl-5-(2-trifluoromethoxy-phenyl)-1H-pyrrole-3-carboxylic acid cyclohexylamide | HCID 58998922 | — |
반응 단계
The title compound was synthesized in analogy to Example 68, using 3-oxo-butyric acid methyl ester as compound of formula R, 2-bromo-1-(2-trifluoromethoxy-phenyl)-ethanone as compound of formula S, 2-aminomethyl-1-cyclohexanol as R3—(CH2)m—NH2 and cyclohexylamine as R1R2NH, MS (ISP) 479.6 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07579369B2 |
| 출처 데이터셋 | uspto-grants-2009_08 |
| ORD ID | ord-7109e7a865ff432c8cf669dc1b4eb931 |
| 출처 메모 | uspto-grants-2009_08 |