Chloroacetyl chloride → 1-(2-oxo-2-piperidin-1-ylethyl)piperazine

HRID 2105866노트

반응식

C(O[C:6]([N:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1)=O)(C)(C)C.ClC[C:16](Cl)=[O:17].[NH:19]1[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1>>[N:8]1([CH2:6][C:16]([N:19]2[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]2)=[O:17])[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]1

참가 물질

반응물 3

HCID 6577Chloroacetyl chloride

HCID 8082Piperidine

HCID 143452tert-Butyl piperazine-1-carboxylate

생성물 1

HCID 27604391-(2-oxo-2-piperidin-1-ylethyl)piperazine

실험 절차

The title compound was prepared from 1-tert-butyloxycarbonyl-piperazine, chloroacetylchloride and piperidine in an analogous manner as described in example 21.

출처 및 근거

ORD 기록: ord-0c5be6d909f24dd0a61eb911277eedb3
출처 데이터셋: uspto-grants-2009_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07579368B2

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