3-(5-Fluoro-2-methoxyphenyl)-3-methylbutan-1-ol → 3-(5-Fluoro-2-methoxyphenyl)-3-methylbutyraldehyde

HRID 2106052노트

반응식

HRID 2106052 반응식
[CH3:1][C:2]([C:7]1[CH:12]=[C:11]([F:13])[CH:10]=[CH:9][C:8]=1[O:14][CH3:15])([CH3:6])[CH2:3][CH2:4][OH:5].[Cr](Cl)([O-])(=O)=O.[NH+]1C=CC=CC=1>C(Cl)Cl>[CH3:6][C:2]([C:7]1[CH:12]=[C:11]([F:13])[CH:10]=[CH:9][C:8]=1[O:14][CH3:15])([CH3:1])[CH2:3][CH:4]=[O:5]

참가 물질

4

반응물 2

HCID 578097383-(5-Fluoro-2-methoxyphenyl)-3-methylbutan-1-olHCID 178418287HCID 178418287, 화합물

생성물 1

HCID 578098963-(5-Fluoro-2-methoxyphenyl)-3-methylbutyraldehyde

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 3-methyl-3-(2-methoxy-5-fluorophenyl)butan-1-ol (3.30 g) in methylene chloride (40 mL) stirred at room temperature was added pyridinium chlorochromate (4.2 g) portionwise over 5 minutes. The mixture was stirred for 3 hours and then filtered through CELITE® filter aid. The solvent was evaporated in vacuo and the residue was fractionated by chromatography over silica gel (methylene chloride-hexane (1:3 to 1:1 gradient)) to give 3-methyl-3-(2-methoxy-5-fluorophenyl)butyraldehyde an oil (2.5 g, 76%).

후처리

  1. filtrationfiltered through CELITE®
  2. filtrationfilter aid
  3. customThe solvent was evaporated in vacuo

출처 및 근거

ORD 기록
ord-cd2c7cdc310e47c08ccff6cf3df05cce
출처 데이터셋
uspto-grants-2009_08
특허 번호
US07579469B2

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