Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzylamine → 1-Benzyl-3-(4-trifluoromethoxy-phenyl)-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzylamine | HCID 7504 | — |
| 반응물 | 4-Trifluoromethoxy-(2-nitro-vinyl)-benzene | HCID 688233 | — |
| 반응물 | tert-Butyl 4-oxopiperidine-1-carboxylate | HCID 735900 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 1-Benzyl-3-(4-trifluoromethoxy-phenyl)-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridine | HCID 11462900 | — |
반응 단계
The title compound (0.28 g) was prepared from 0.50 g of 4-oxo-piperidine-1-carboxylic acid tert-butyl ester, 274 μL of benzylamine, and 0.59 g of 1-trifluoromethoxy-4-(2-nitro-vinyl)-benzene using CH2Cl2 as the solvent. MS (ESI): exact mass calculated for C21H19F3N2O, 372.14; found, m/z 373.2 [M+H]+. 1H NMR (400 MHz, CD3OD): 7.44-7.41 (m, 2H), 7.37-7.26 (m, 5H), 7.19-7.17 (m, 3H), 5.15 (s, 2H), 4.37 (s, 2H), 3.51 (t, J=6.3 Hz, 2H), 2.87 (t, J=6.3 Hz, 2H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07579470B2 |
| 출처 데이터셋 | uspto-grants-2009_08 |
| ORD ID | ord-cd08bb8f47f5437ea67794b7e9aac088 |
| 출처 메모 | uspto-grants-2009_08 |