Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1,2-Ethanediamine, N1,N1,N2-trimethyl- → 4-chloro-7-(1-(tert-butoxycarbonyl)-5-[N-(2-(dimethylamino)ethyl)-N-methylaminomethyl]indol-2-yl)isoindolinone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1,2-Ethanediamine, N1,N1,N2-trimethyl- | HCID 67338 | — |
| 반응물 | Sodium triacetoxyborohydride | HCID 5049666 | — |
| 반응물 | 4-Chloro-7-[1-(tert-butoxycarbonyl)-5-formylindol-2-yl]isoindolinone | HCID 86628227 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 4-chloro-7-(1-(tert-butoxycarbonyl)-5-[N-(2-(dimethylamino)ethyl)-N-methylaminomethyl]indol-2-yl)isoindolinone | HCID 68493529 | — |
반응 단계
In a similar manner to Step 1 of Example 56, 4-chloro-7-[1-(tert-butoxycarbonyl)-5-formylindol-2-yl]isoindolinone (20.0 mg, 0.0487 mmol) was dissolved in dichloromethane (0.5 mL). The solution was treated with N,N,N′-trimethylethylenediamine (32 mg, 0.20 mmol) and sodium triacetoxyborohydride (32 mg, 0.15 mmol) to obtain 4-chloro-7-(1-(tert-butoxycarbonyl)-5-[N-(2-(dimethylamino)ethyl)-N-methylaminomethyl]indol-2-yl)isoindolinone.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07745641B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-fc13530c95d2404184b3ef307d895953 |
| 출처 메모 | uspto-grants-2010_06 |