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Ethanol → Sodium 5-{1-ethoxycarbonyl-1-[2-(3-phenylureido)thiazol-4-yl]met hylene]rhodanine-3-acetate tetrahydrate

HRID 2107179
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HRID 2107179 반응식
[CH2:1]([O:3][C:4]([C:6](=[C:22]1[S:26][C:25](=[S:27])[N:24]([CH2:28][C:29]([OH:31])=[O:30])[C:23]1=[O:32])[C:7]1[N:8]=[C:9]([NH:12][C:13]([NH:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[O:14])[S:10][CH:11]=1)=[O:5])[CH3:2].C[O-:34].[Na+:35].C([OH:38])C>CCOCC>[OH2:3].[OH2:38].[OH2:34].[OH2:3].[CH2:1]([O:3][C:4]([C:6](=[C:22]1[S:26][C:25](=[S:27])[N:24]([CH2:28][C:29]([O-:31])=[O:30])[C:23]1=[O:32])[C:7]1[N:8]=[C:9]([NH:12][C:13]([NH:15][C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)=[O:14])[S:10][CH:11]=1)=[O:5])[CH3:2].[Na+:35]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 702EthanolHCID 10942334Sodium MethoxideHCID 541363965-{1-Ethoxycarbonyl-1-[2-(3-phenylureido)thiazol-4-yl]methylene}rhodanine acetic acid

생성물 1

HCID 86744026Sodium 5-{1-ethoxycarbonyl-1-[2-(3-phenylureido)thiazol-4-yl]met hylene]rhodanine-3-acetate tetrahydrate

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

A mixture comprising 2.46 g of 5-{1-ethoxycarbonyl-1-[2-(3-phenylureido)thiazol-4-yl]methylene]rhodanine-3-acetic acid, 0.54 g of sodium methoxide and 30 ml of absolute ethanol was stirred for 1 hour under ice-cooling, then treated by ultrasonication at room temperature for 30 minutes. The reaction mixture was then poured into anhydrous ether and the crystalline product which precipitated out was collected by filtration, giving the desired compound as a reddish-brown powder.

후처리

  1. temperaturecooling
  2. additiontreated by ultrasonication at room temperature for 30 minutes
  3. customthe crystalline product which precipitated out
  4. filtrationwas collected by filtration

출처 및 근거

ORD 기록
ord-0d806cc2c03f45b2a55265ea996eb2ae
출처 데이터셋
uspto-grants-1990_06
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04933355

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