2-Tritylaminothiazole-4-methanol → 2-(Tritylamino)thiazole-4-carbaldehyde

HRID 2107234노트

반응식

HRID 2107234 반응식
[C:1]([NH:20][C:21]1[S:22][CH:23]=[C:24]([CH2:26][OH:27])[N:25]=1)([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>[O-2].[O-2].[Mn+4].CC(C)=O>[C:1]([NH:20][C:21]1[S:22][CH:23]=[C:24]([CH:26]=[O:27])[N:25]=1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)([C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

참가 물질

4

반응물 1

HCID 150535522-Tritylaminothiazole-4-methanol

생성물 1

HCID 150535692-(Tritylamino)thiazole-4-carbaldehyde

시약·촉매·용매 2

HCID 178418406HCID 178418406, 화합물촉매HCID 180Acetone용매

실험 절차

A mixture comprising 0.5 g of 2-tritylaminothiazole-4-methanol, 5 g of manganese dioxide and 20 ml of acetone was stirred at room temperature for 60 hours. The manganese dioxide was filtered off and the filtrate was evaporated under reduced pressure. The residue was purified by silica gel column chromatography. using as eluent a 10:1 by volume mixture of benzene and ethyl acetate, giving the desired compound as a brownish-orange powder.

후처리

  1. filtrationThe manganese dioxide was filtered off
  2. customthe filtrate was evaporated under reduced pressure
  3. customThe residue was purified by silica gel column chromatography
  4. additionby volume mixture of benzene and ethyl acetate

출처 및 근거

ORD 기록
ord-71e2dde376fb49e2bd745c0c5157ab89
출처 데이터셋
uspto-grants-1990_06
특허 번호
US04933355

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