Ethyl bromopyruvate → Ethyl 2-[(2-methylphenyl)amino]-4-thiazolecarboxylate

HRID 2107262노트

반응식

[C:1]1([CH3:11])[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[NH:7][C:8]([NH2:10])=[S:9].Br[CH2:13][C:14](=O)[C:15]([O:17][CH2:18][CH3:19])=[O:16]>>[C:1]1([CH3:11])[C:2]([NH:7][C:8]2[S:9][CH:13]=[C:14]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[N:10]=2)=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

반응물 2

HCID 66144Ethyl bromopyruvate

HCID 2787703N-(2-Methylphenyl)thiourea

생성물 1

HCID 1284666Ethyl 2-[(2-methylphenyl)amino]-4-thiazolecarboxylate

실험 절차

Following a procedure similar to that described in Preparation 42, the desired compound was prepared from 20 g of o-tolylthiourea, 23 g of ethyl bromopyruvate and 200 ml of giving the desired compound as pale yellow prismatic crystals having the following physical properties.

후처리

customthat described in Preparation 42

출처 및 근거

ORD 기록: ord-da3135c3ccd34c7e8119818b079f7594
출처 데이터셋: uspto-grants-1990_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04933355

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