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Sodium Iodide → 3-[4-[1-(6-Chloro-1,2-benzisothiazol-3-yl)-4-piperazinyl]butyl]-1-thia-3-azaspiro[4.5]decan-4-one hydrochloride

HRID 2107490
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반응식

HRID 2107490 반응식
Br[CH2:2][CH2:3][CH2:4][CH2:5][N:6]1[CH2:10][C:9]2([CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]2)[S:8](=O)[CH2:7]1.[Cl:17][C:18]1[CH:32]=[CH:31][C:21]2[C:22]([N:25]3[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]3)=[N:23][S:24][C:20]=2[CH:19]=1.C([O-])([O-])=[O:34].[K+].[K+].[Na+].[I-]>C(#N)C>[ClH:17].[Cl:17][C:18]1[CH:32]=[CH:31][C:21]2[C:22]([N:25]3[CH2:30][CH2:29][N:28]([CH2:2][CH2:3][CH2:4][CH2:5][N:6]4[C:10](=[O:34])[C:9]5([CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]5)[S:8][CH2:7]4)[CH2:27][CH2:26]3)=[N:23][S:24][C:20]=2[CH:19]=1
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참가 물질

6

반응물 4

HCID 5238Sodium IodideHCID 11430Potassium CarbonateHCID 104911256-Chloro-1,2-benzisothiazol-3-yl piperazineHCID 569960223-(4-Bromobutyl)-1-thia-3-azaspiro[4.5]decanone

생성물 1

HCID 148561853-[4-[1-(6-Chloro-1,2-benzisothiazol-3-yl)-4-piperazinyl]butyl]-1-thia-3-azaspiro[4.5]decan-4-one hydrochloride수율 76.6%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

반응 조건

온도
80 °C

실험 절차

A mixture of 3-(4-bromobutyl)-1-thia-3-azaspiro[4.5]decanone (2.7 g), 6-chloro-1,2-benzisothiazol-3-yl piperazine (2.0 g), K2CO3 (2.2 g) and NaI (200 mg) in acetonitrile (100 ml) was heated at 80° C. for 8 hours and the product was processed in substantially the same manner as in Example 10 to afford 1.557 g of solid, m.p. 202°-205° C.

출처 및 근거

ORD 기록
ord-b56550e5c40949cab423704a356246f6
출처 데이터셋
uspto-grants-1990_06
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04933453

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