1,3-Benzenediacetonitrile, 5-(hydroxymethyl)-alpha1,alpha1,alpha3,alpha3-tetramethyl- → 2-[3-(2-Cyanopropan-2-yl)-5-formylphenyl]-2-methylpropanenitrile

HRID 2107762노트

반응식

HRID 2107762 반응식
[OH:1][CH2:2][C:3]1[CH:4]=[C:5]([C:14]([CH3:18])([CH3:17])[C:15]#[N:16])[CH:6]=[C:7]([C:9]([CH3:13])([CH3:12])[C:10]#[N:11])[CH:8]=1.[Cr](Cl)([O-])(=O)=O.[NH+]1C=CC=CC=1>ClCCl>[CH:2]([C:3]1[CH:8]=[C:7]([C:9]([CH3:13])([CH3:12])[C:10]#[N:11])[CH:6]=[C:5]([C:14]([CH3:18])([CH3:17])[C:15]#[N:16])[CH:4]=1)=[O:1]

참가 물질

4

반응물 2

HCID 193493981,3-Benzenediacetonitrile, 5-(hydroxymethyl)-alpha1,alpha1,alpha3,alpha3-tetramethyl-HCID 178418287HCID 178418287, 화합물

생성물 1

HCID 115069812-[3-(2-Cyanopropan-2-yl)-5-formylphenyl]-2-methylpropanenitrile

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A solution of 2,2'-(5-hydroxymethyl-1,3-phenylene)di(2-methylpropiononitrile), (1.9 g), in dichloromethane (20 ml) was treated with pyridinium chlorochromate (2.15 g) and stirred at room temperature for 1.5 h. The reaction mixture was subjected to flash column chromatography, eluting with dichloromethane, to give 2,2'-(5-formyl- 1,3-phenylene)di(2-methylpropiononitrile), mp. 145°-147°.

후처리

  1. washeluting with dichloromethane

출처 및 근거

ORD 기록
ord-e9822b04408541c78c6f630dcdefbd99
출처 데이터셋
uspto-grants-1990_06
특허 번호
US04935437

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