Potassium Iodide → HCID 23045048, 화합물

HRID 2108037노트

반응식

HRID 2108037 반응식
Br[CH2:2][CH2:3][CH2:4][CH2:5][O:6][CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=1.CC(=O)[CH2:17][C:18](=[O:20])[CH3:19].C(=O)([O-])[O-].[K+].[K+].[I-].[K+]>C(O)C.CCOCC>[N:10]1[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=1[CH2:8][CH2:7][O:6][CH2:5][CH2:4][CH2:3][CH2:2][CH2:17][C:18](=[O:20])[CH3:19]

참가 물질

7

반응물 4

HCID 4875Potassium IodideHCID 11430Potassium CarbonateHCID 31261AcetylacetoneHCID 230450722-[2-(4-Bromobutoxy)ethyl]pyridine

생성물 1

HCID 23045048HCID 23045048, 화합물수율 83.3%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 3283Diethyl Ether용매

실험 절차

A mixture of 2-[2-[(4-bromobutyl)oxy]ethyl]pyridine (6.2 g), 2,4-pentanedione (3.61 g), potassium carbonate (4.75 g) and potassium iodide (3.95 g) in ethanol (125 ml) was stirred and heated overnight under reflux. The solids were removed by filtration and the filtrate evaporated to leave a dark brown semi-solid. Addition of ether (200 ml) and filtration of the solid produced a brown solution which was evaporated to give a brown oil (4.71 g). Purification by FCC eluting with ether-hexane (1:1→3:1) gave the title compound as a pale yellow oil (1.93 g).

후처리

  1. temperatureheated overnight
  2. temperatureunder reflux
  3. customThe solids were removed by filtration
  4. customthe filtrate evaporated
  5. customto leave a dark brown semi-solid
  6. customproduced a brown solution which
  7. customwas evaporated

출처 및 근거

ORD 기록
ord-db34ccea9f4b4518acbcdfeabed8f586
출처 데이터셋
uspto-grants-1990_06
특허 번호
US04937251

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