Piperazine → 5-Iodo-2-(piperazin-1-yl)pyrimidine
반응식
Cl[C:2]1[N:7]=[CH:6][C:5]([I:8])=[CH:4][N:3]=1.[NH:9]1[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]1>CN(C)C=O>[I:8][C:5]1[CH:4]=[N:3][C:2]([N:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)=[N:7][CH:6]=1참가 물질
4
실험 절차
0.02 mol of 2-chloro-5-iodopyrimidine, 0.06 mol of piperazine and 100 ml of absolute dimethylformamide are heated to 100° for 45 minutes and then evaporated. The crystalline residue is shaken with potassium bicarbonate solution and methylene chloride. The substance contained in the methylene chloride phase is purified by column chromatography over silica gel 60. The amine obtained by elution with methylene chloride/methanol (7:3) is stirred with isopropyl ether and filtered off with suction.
후처리
- customevaporated
- customis purified by column chromatography over silica gel 60
출처 및 근거
- ORD 기록
- ord-e687f32e07f74c639c66782c91aa894f
- 출처 데이터셋
- uspto-grants-1990_06
- 특허 번호
- US04937343
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