1-Propanol → Propyl 4-hydroxy-3-methoxyphenylacetate

HRID 2108339

반응식

HRID 2108339 반응식
[OH:1][C:2]1[CH:10]=[CH:9][C:5]([CH2:6][CH2:7][OH:8])=[CH:4][C:3]=1[O:11][CH3:12].[CH2:13]([OH:16])[CH2:14][CH3:15]>S(=O)(=O)(O)O>[CH2:13]([O:16][C:7](=[O:8])[CH2:6][C:5]1[CH:9]=[CH:10][C:2]([OH:1])=[C:3]([O:11][CH3:12])[CH:4]=1)[CH2:14][CH3:15]

참가 물질

4

반응물 2

HCID 10311-PropanolHCID 16928Homovanillyl alcohol

생성물 1

HCID 104310Propyl 4-hydroxy-3-methoxyphenylacetate

시약·촉매·용매 1

HCID 1118Sulfuric Acid촉매

반응 조건

온도
100 °C

실험 절차

4-Hydroxy-3-methoxyphenethyl alcohol (Sigma-Aldrich) was dissolved in anhydrous 1-propanol. To this solution ˜5 drops of concentrated sulphuric acid were added and the solution was heated at 100° C. for 3-5 hours in a pressure tube. When the reaction was complete, the 1-propanol was removed under reduced pressure, the resulting oil was diluted with ethyl acetate and washed with saturated sodium bicarbonate solution, distilled water, and then brine. The solution was dried over magnesium sulfate and filtered and the solvent was removed under reduced pressure, giving 15-A as a red oil in almost quantitative yield.

후처리

  1. customthe 1-propanol was removed under reduced pressure
  2. additionthe resulting oil was diluted with ethyl acetate
  3. washwashed with saturated sodium bicarbonate solution
  4. distillationdistilled water
  5. dry with materialThe solution was dried over magnesium sulfate
  6. filtrationfiltered
  7. customthe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-c7ad87354f2b4620882fd2cfcce6d9df
출처 데이터셋
uspto-grants-2009_04
특허 번호
US07514425B2

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