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Dimethylformamide → 5-(2,6-Dimethyl-4-triisopropylsilanyloxybenzyl)-2-methoxymethoxybenzaldehyde

HRID 2108634
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HRID 2108634 반응식
[CH3:1][C:2]1[CH:18]=[C:17]([O:19][Si:20]([CH:27]([CH3:29])[CH3:28])([CH:24]([CH3:26])[CH3:25])[CH:21]([CH3:23])[CH3:22])[CH:16]=[C:15]([CH3:30])[C:3]=1[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][O:13][CH3:14])=[CH:7][CH:6]=1.CN(CCN(C)C)C.[Li]CCCC.CN([CH:47]=[O:48])C>CCOCC>[CH3:30][C:15]1[CH:16]=[C:17]([O:19][Si:20]([CH:27]([CH3:29])[CH3:28])([CH:21]([CH3:23])[CH3:22])[CH:24]([CH3:26])[CH3:25])[CH:18]=[C:2]([CH3:1])[C:3]=1[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][O:13][CH3:14])=[C:7]([CH:6]=1)[CH:47]=[O:48]
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참가 물질

6

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HCID 6228DimethylformamideHCID 8037N,N,N',N'-TetramethylethylenediamineHCID 666426914-(2,6-Dimethyl-4-triisopropylsilanyloxybenzyl)-methoxymethoxybenzeneHCID 178418339Butyllithium

생성물 1

HCID 866034575-(2,6-Dimethyl-4-triisopropylsilanyloxybenzyl)-2-methoxymethoxybenzaldehyde수율 98.7%

시약·촉매·용매 1

HCID 3283
Diethyl Ether
용매

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온도
0 °C

실험 절차

To a solution of 4-(2,6-dimethyl-4-triisopropylsilanyloxybenzyl)-methoxymethoxybenzene (2.0 g, 4.66 mmol) in ether was added TMEDA (1.05 mL, 6.99 mmol), followed by nBuLi (2.5 M in THF, 2.8 mL) at −20° C. The reaction mixture was warmed up to 0° C. and stirred for 1 h DMF (0.72 mL, 9.32 mmol) was then added and after stirring at 0° C. for 2 h, the reaction mixture was quenched with a saturated solution of NH4Cl and diluted with EtOAc. The water layer was extracted with EtOAc and the combined organic extracts were dried (MgSO4), filtered and concentrated to give the crude product 5-(2,6-dimethyl-4-triisopropylsilanyloxybenzyl)-2-methoxymethoxy-benzaldehyde (2.1 g, 98%): 1H NMR (300 MHz, d6-DMSO): δ 10.33 (s, 1H), 7.24 (m, 3H), 6.58 (s, 2H), 5.31 (s, 2H), 3.91 (s, 2H), 3.33 (s, 6H), 1.23 (m, 3H), 1.06 (m, 18H). TLC conditions: Uniplate silica gel, 250 microns; Mobile phase=ethyl acetate-hexanes (1:9); Rf=0.55.

후처리

  1. additionwas then added
  2. customthe reaction mixture was quenched with a saturated solution of NH4Cl
  3. additiondiluted with EtOAc
  4. extractionThe water layer was extracted with EtOAc
  5. dry with materialthe combined organic extracts were dried (MgSO4)
  6. filtrationfiltered
  7. concentrationconcentrated

출처 및 근거

ORD 기록
ord-1e179362c3574aff800cbe029cf12e7d
출처 데이터셋
uspto-grants-2009_04
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07514419B2

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