Trifluoroacetic acid → 2-Thiophenamine, 4-[1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridin-3-yl]-

HRID 2108748노트

반응식

HRID 2108748 반응식
[S:1]([N:11]1[C:15]2=[N:16][CH:17]=[CH:18][CH:19]=[C:14]2[C:13]([C:20]2[CH:21]=[C:22]([NH:25]C(=O)OC(C)(C)C)[S:23][CH:24]=2)=[CH:12]1)([C:4]1[CH:10]=[CH:9][C:7]([CH3:8])=[CH:6][CH:5]=1)(=[O:3])=[O:2].C(O)(C(F)(F)F)=O>C(Cl)Cl>[C:7]1([CH3:8])[CH:6]=[CH:5][C:4]([S:1]([N:11]2[C:15]3=[N:16][CH:17]=[CH:18][CH:19]=[C:14]3[C:13]([C:20]3[CH:21]=[C:22]([NH2:25])[S:23][CH:24]=3)=[CH:12]2)(=[O:3])=[O:2])=[CH:10][CH:9]=1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 57633069Carbamic acid, [4-[1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridin-3-yl]-2-thienyl]-, 1,1-dimethylethyl ester (9CI)

생성물 1

HCID 576330322-Thiophenamine, 4-[1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridin-3-yl]-

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

tert-Butyl 4-(1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)thiophen-2-ylcarbamate (120 mg, 0.26 mmol) was dissolved in 2 mL CH2Cl2, 2 mL TFA. After 15 minutes the reaction mixture was concentrated to an oil, dissolved in EtOAc, and washed with 0.1 NaOH. The organic layer was dried to a brown oil which was used as obtained.

후처리

  1. concentrationAfter 15 minutes the reaction mixture was concentrated to an oil
  2. dissolutiondissolved in EtOAc
  3. washwashed with 0.1 NaOH
  4. customThe organic layer was dried to a brown oil which
  5. customas obtained

출처 및 근거

ORD 기록
ord-87eb6376fd5f48e797626d5080cad636
출처 데이터셋
uspto-grants-2009_04
특허 번호
US07514448B2

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