HCID 69056186, 화합물 → 3-(4-methylphenyl)-1H-indazole

HRID 2108995노트

반응식

HRID 2108995 반응식
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:16]3[CH2:15][CH2:14][CH2:13][CH2:12][C:11]=3[NH:10][N:9]=2)=[CH:4][CH:3]=1>C1[C@H]2[C@@H](CCCC2)CCC1.[Pd]>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[NH:10][N:9]=2)=[CH:6][CH:7]=1

참가 물질

4

반응물 1

HCID 69056186HCID 69056186, 화합물

생성물 1

HCID 98777323-(4-methylphenyl)-1H-indazole수율 82%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 178420442HCID 178420442, 화합물용매

실험 절차

Into the solution of compound 8 (12.3 g, 0.058 mol) in trans-decahydronaphthalene (trans-decalin) was added 10% Pd/C (2.7 g), and the mixture was heated under reflux for 4 h, and then concentrated in vacuo in oil bath until there were about 20 mL solution left. Petroleum ether (80 mL) was added into the residue while hot, and the mixture was well mixed by shaking. The mixture was allowed to precipitate upon cooling to afford 3-(4-methylphenyl)-1H-indazole (10, 9.85 g, 82% yield).

후처리

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 4 h
  3. concentrationconcentrated in vacuo in oil bath until there
  4. waitleft
  5. additionPetroleum ether (80 mL) was added into the residue while hot, and the mixture
  6. additionwas well mixed
  7. customto precipitate
  8. temperatureupon cooling

출처 및 근거

ORD 기록
ord-93a2cf5479a94d28888e08144c378f28
출처 데이터셋
uspto-grants-2009_04
특허 번호
US07514465B2

반응 노트

불러오는 중…