Triethylamine → HCID 178473965, 화합물

HRID 2109016노트

반응식

HRID 2109016 반응식
[C:1]([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([Cl:13])[CH:11]=2)[CH2:6][C:5]1=[O:14])(=[O:3])[CH3:2].[I:15][C:16]1[CH:17]=[C:18]([CH:22]=[CH:23][CH:24]=1)[C:19](O)=[O:20].CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F.C(N(CC)CC)C>CN(C)C=O.O>[C:1]([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([Cl:13])[CH:11]=2)[C:6](=[C:19]([OH:20])[C:18]2[CH:22]=[CH:23][CH:24]=[C:16]([I:15])[CH:17]=2)[C:5]1=[O:14])(=[O:3])[CH3:2]

참가 물질

7

반응물 4

HCID 8471TriethylamineHCID 120603-Iodobenzoic acidHCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 116441611-Acetyl-6-chloroindolin-2-one

생성물 1

HCID 178473965HCID 178473965, 화합물

시약·촉매·용매 2

HCID 962Water용매HCID 6228Dimethylformamide용매

실험 절차

10.5 g 1-acetyl-6-chloro-2-indolinone (educt V.1), 13.6 g 3-iodobenzoic acid and 17.7 g TBTU are placed in 100 ml of dimethylformamide, 35 ml triethylamine are added and the mixture is stirred for 12 hours at ambient temperature. After this time the solvent is eliminated, the residue is combined with water, suction filtered and washed with a little water, methanol and ether and dried in vacuo at 100° C.

후처리

  1. filtrationfiltered
  2. washwashed with a little water, methanol and ether
  3. customdried in vacuo at 100° C.

출처 및 근거

ORD 기록
ord-876d780ab8234cd5a96eb486e27c6a74
출처 데이터셋
uspto-grants-2009_04
특허 번호
US07514468B2

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