tert-Butyl 2-bromopropanoate → 1,1-Dimethylethyl N-[4-cyano-3-(trifluoromethyl)phenyl]-N-(3,3,3-trifluoropropyl)alaninate

HRID 2109109노트

반응식

HRID 2109109 반응식
[F:1][C:2]([F:19])([F:18])[C:3]1[CH:10]=[C:9]([NH:11][CH2:12][CH2:13][C:14]([F:17])([F:16])[F:15])[CH:8]=[CH:7][C:4]=1[C:5]#[N:6].Br[CH:21]([CH3:29])[C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23]>>[C:5]([C:4]1[CH:7]=[CH:8][C:9]([N:11]([CH2:12][CH2:13][C:14]([F:17])([F:16])[F:15])[C@H:21]([C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23])[CH3:29])=[CH:10][C:3]=1[C:2]([F:18])([F:19])[F:1])#[N:6]

참가 물질

3

반응물 2

HCID 545327tert-Butyl 2-bromopropanoateHCID 576337572-(Trifluoromethyl)-4-[(3,3,3-trifluoropropyl)amino]benzonitrile

생성물 1

HCID 866319971,1-Dimethylethyl N-[4-cyano-3-(trifluoromethyl)phenyl]-N-(3,3,3-trifluoropropyl)alaninate

실험 절차

Synthesized as described in example 1B using 2-(trifluoromethyl)-4-[(3,3,3-trifluoropropyl)amino]benzonitrile and 1,1-dimethylethyl 2-bromopropanoate. 1H NMR (400 MHz, CDCl3) δ 7.67 (d, J=8.8 Hz, 1H), 7.0 (d, J=2.6 Hz, 1H), 6.85 (dd, J=8.8, 2.6 Hz, 1H), 4.37 (q, J=7.3 Hz, 1H), 3.74 (t, J=8.1 Hz, 2H), 2.62-2.38 (m, 2H), 1.61 (d, J=7.3 Hz, 3H), 1.45 (s, 9H).

후처리

  1. customSynthesized

출처 및 근거

ORD 기록
ord-633d55b20ce346088875046b8f0df4e4
출처 데이터셋
uspto-grants-2009_04
특허 번호
US07514470B2

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