2-(Tributylstannyl)furan → 7-Amino-4-(furan-2-yl)isoindolinone

HRID 21092노트

반응식

HRID 21092 반응식
[NH2:1][C:2]1[CH:3]=[CH:4][C:5](Br)=[C:6]2[C:10]=1[C:9](=[O:11])[NH:8][CH2:7]2.C([Sn](CCCC)(CCCC)[C:18]1[O:19][CH:20]=[CH:21][CH:22]=1)CCC>C1COCC1.Cl[Pd](Cl)([P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1>[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([C:18]2[O:19][CH:20]=[CH:21][CH:22]=2)=[C:6]2[C:10]=1[C:9](=[O:11])[NH:8][CH2:7]2

참가 물질

5

반응물 2

HCID 43936882-(Tributylstannyl)furanHCID 197019327-Amino-4-bromo-2,3-dihydroisoindol-1-one

생성물 1

HCID 684927397-Amino-4-(furan-2-yl)isoindolinone수율 55%

시약·촉매·용매 2

HCID 178418476HCID 178418476, 화합물촉매HCID 8028Tetrahydrofuran용매

실험 절차

In a similar manner to Step 1 of Example 10, 7-amino-4-bromoisoindolinone (234 mg, 1.03 mmol) was dissolved in THF (11.6 mL), and the solution was treated with 2-(tributylstannyl)furane (0.649 mL, 2.06 mmol) and bis(triphenylphosphine)dichloropalladium (58 mg, 0.082 mmol), followed by purification by preparative thin-layer chromatography (chloroform/acetone=4/1, chloroform/methanol=12/1) to obtain 7-amino-4-(furan-2-yl)isoindolinone (121 mg, yield 55%).

후처리

  1. customfollowed by purification by preparative thin-layer chromatography (chloroform/acetone=4/1, chloroform/methanol=12/1)

출처 및 근거

ORD 기록
ord-68c7b12d71e149028aac55c12e0e9711
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07745641B2

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