tert-Butyl carbazate → Tert-butyl 2-(1-methylpiperidin-4-ylidene)hydrazinecarboxylate

HRID 2109260

반응식

HRID 2109260 반응식
[CH3:1][N:2]1[CH2:7][CH2:6][C:5](=O)[CH2:4][CH2:3]1.[C:9]([NH:16][NH2:17])([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10]>>[CH3:1][N:2]1[CH2:7][CH2:6][C:5](=[N:17][NH:16][C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])[CH2:4][CH2:3]1

참가 물질

3

반응물 2

HCID 70091tert-Butyl carbazateHCID 740491-Methyl-4-piperidone

생성물 1

HCID 21097379Tert-butyl 2-(1-methylpiperidin-4-ylidene)hydrazinecarboxylate수율 32%

실험 절차

A solution of 11.2 g (99.0 mmol) of 1-methyl-piperid-4-one and 13.0 g (100 mmol) of Boc-hydrazine in 150 mL of hexanes was refluxed for 30 minutes. The hot solution was dried over MgSO4, filtered, and allowed to cool. The resulting crystals were isolated and recrystallized from Et2O to provide 7.2 g of tert-butyl N′-(1-Methyl-piperidin-4-ylidene)-hydrazinecarboxylate as a white solid.

후처리

  1. dry with materialThe hot solution was dried over MgSO4
  2. filtrationfiltered
  3. temperatureto cool
  4. customThe resulting crystals were isolated
  5. customrecrystallized from Et2O

출처 및 근거

ORD 기록
ord-bd36b320da88410b94f7e7655875b826
출처 데이터셋
uspto-grants-2009_04
특허 번호
US07514458B2

연결된 노트

불러오는 중…