Cesium carbonate → 4-[2-(2-nitrophenoxy)ethyl]morpholine

HRID 2109960

반응식

HRID 2109960 반응식
F[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N+:8]([O-:10])=[O:9].[O:11]1[CH2:16][CH2:15][N:14]([CH:17](O)[CH3:18])[CH2:13][CH2:12]1.C(=O)([O-])[O-:21].[Cs+].[Cs+]>CN(C)C=O>[N+:8]([C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[O:21][CH2:18][CH2:17][N:14]1[CH2:15][CH2:16][O:11][CH2:12][CH2:13]1)([O-:10])=[O:9]

참가 물질

5

반응물 3

HCID 10796Cesium carbonateHCID 738951-Fluoro-2-nitrobenzeneHCID 30293761-Morpholinoethanol

생성물 1

HCID 8673614-[2-(2-nitrophenoxy)ethyl]morpholine

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

As in Example 1 of WO 00/59883, 14.11 g (100 mmol) of 2-fluoronitrobenzene, 14.45 g (100 mmol) of morpholinoethanol, 35.8 g (100 mmol) of cesium carbonate and 100 mL of dimethylformamide were allowed to agitate at room temperature for 7 days. The mixture was then filtered, the dimethylformamide was removed in a rotary evaporator, and the residue was distilled in a bulb tube still at 4 mbar and a furnace temperature of 160 to 170° C.

후처리

  1. filtrationThe mixture was then filtered
  2. customthe dimethylformamide was removed in a rotary evaporator
  3. distillationthe residue was distilled in a bulb tube still at 4 mbar
  4. customa furnace temperature of 160 to 170° C.

출처 및 근거

ORD 기록
ord-9e10c9e77376474987ad0d0b966fbb38
출처 데이터셋
uspto-grants-2009_04
특허 번호
US07517367B2

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