4-Methylphenyl isocyanate → HCID 23023097, 화합물

HRID 2110082노트

반응식

HRID 2110082 반응식
[C:1]1([CH3:10])[CH:6]=[CH:5][C:4]([N:7]=[C:8]=[O:9])=[CH:3][CH:2]=1.[CH3:11][O:12][C:13]1[CH:19]=[C:18]([O:20][CH3:21])[C:17]([C:22]([F:25])([F:24])[F:23])=[CH:16][C:14]=1[NH2:15]>CCOC(C)=O>[CH3:11][O:12][C:13]1[CH:19]=[C:18]([O:20][CH3:21])[C:17]([C:22]([F:24])([F:23])[F:25])=[CH:16][C:14]=1[NH:15][C:8]([NH:7][C:4]1[CH:5]=[CH:6][C:1]([CH3:10])=[CH:2][CH:3]=1)=[O:9]

참가 물질

4

반응물 2

HCID 693254-Methylphenyl isocyanateHCID 27800032,4-dimethoxy-5-(trifluoromethyl)aniline

생성물 1

HCID 23023097HCID 23023097, 화합물수율 89.9%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

p-Tolyl isocyanate (0.16 mL, 1.24 mmol) was added to a solution of 2,4-dimethoxy-5-(trifluoromethyl)aniline (0.25 g, 1.13 mmol) in EtOAc (3 mL) and the resulting mixture was stirred at room temp. for 18 h. The resulting precipitate was washed with Et2O to give the title compound as a white solid (0.36 g): 1H-NMR (CDCl3) δ 2.21 (s, 3H), 3.97 (s, 3H), 3.86 (s, 3H), 6.88 (s, 1H), 7.05 (d, J=8.5 Hz, 2H), 7.29 (d, J=8.5 Hz, 2H), 8.13 (s, 1H), 8.33 (s, 1H), 9.09 (s, 1H); FAB-MS m/z 355 ((M+1)+). B1e. General Method for the Reaction of an Aryl Amine with an Aryl Isocyanate

후처리

  1. washThe resulting precipitate was washed with Et2O

출처 및 근거

ORD 기록
ord-5db46d012927401393f118a0eb664905
출처 데이터셋
uspto-grants-2009_04
특허 번호
US07517880B2

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