alpha-Naphthyl isocyanate → HCID 9840976, 화합물

HRID 2110083노트

반응식

HRID 2110083 반응식
[NH2:1][C:2]1[C:11]([O:12][CH3:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=1.[C:14]1([N:24]=[C:25]=[O:26])[C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[CH:17]=[CH:16][CH:15]=1>C(Cl)Cl>[CH3:13][O:12][C:11]1[C:2]([NH:1][C:25]([NH:24][C:14]2[C:23]3[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=3)[CH:17]=[CH:16][CH:15]=2)=[O:26])=[CH:3][C:4]2[C:9]([CH:10]=1)=[CH:8][CH:7]=[CH:6][CH:5]=2

참가 물질

4

반응물 2

HCID 66589alpha-Naphthyl isocyanateHCID 2351413-Methoxynaphthalen-2-amine

생성물 1

HCID 9840976HCID 9840976, 화합물수율 90%

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

To a solution of 2-amino-3-methoxynaphthalene (0.253 g, 1.50 mmol) in CH2Cl2 (3 mL) at room temp. was added a solution of 1-naphthyl isocyanate (0.247 g, 1.50 mmol) in CH2Cl2 (2 mL) and the resulting mixture was allowed to stir overnight. The resulting precipitate was separated and washed with CH2Cl2 to give the desired urea as a white powder (0.450 g, 90%): mp 235-236° C.; 1H-NMR (DMSO-d6) δ 4.04 (s, 3H), 7.28-7.32 (m, 2H), 7.38 (s, 1H), 7.44-7.72 (m, 6H), 7.90-7.93 (m, 1H), 8.05-8.08 (m, 1H), 8.21-8.24 (m, 1H), 8.64 (s, 1H), 9.03 (s, 1H), 9.44 (s, 1H); FAB-MS m/z 343 ((M+H)+). B1f. General Method for the Reaction of an Aryl Amine with an Aryl Isocyanate

후처리

  1. customThe resulting precipitate was separated
  2. washwashed with CH2Cl2

출처 및 근거

ORD 기록
ord-3a82f2efaa4042e68cbafd3fe773dc62
출처 데이터셋
uspto-grants-2009_04
특허 번호
US07517880B2

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