Ammonia → 9-Methyl-8-phenylpurine-6-ylamine

HRID 2110102노트

반응식

HRID 2110102 반응식
Cl[C:2]1[N:10]=[CH:9][N:8]=[C:7]2[C:3]=1[N:4]=[C:5]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[N:6]2[CH3:11].[NH3:18]>>[CH3:11][N:6]1[C:5]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[N:4][C:3]2[C:7]1=[N:8][CH:9]=[N:10][C:2]=2[NH2:18]

참가 물질

3

반응물 2

HCID 222Ammonia2회HCID 11230310HCID 11230310, 화합물

생성물 1

HCID 3085319-Methyl-8-phenylpurine-6-ylamine

반응 조건

온도
-196 °C

실험 절차

6-chloro-9-methyl-8-phenylpurine was added in a steel vial to ammonia cooled to −196° C. using liquid nitrogen. The reaction mixture was allowed to warm to 16° C. for 70 hours; after that, the ammonia was allowed to evaporate at room temperature and the residue was chromatographed and/or crystallized to give 9-methyl-8-phenylpurine-6-ylamine, a compound of Formula (I).

후처리

  1. temperatureto warm to 16° C. for 70 hours
  2. customto evaporate at room temperature
  3. customthe residue was chromatographed
  4. customcrystallized

출처 및 근거

ORD 기록
ord-00ada8958a4a4830b744c69d3179b0a2
출처 데이터셋
uspto-grants-2009_04
특허 번호
US07517888B2

반응 노트

불러오는 중…