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Trifluoroacetic acid → Trifluoroacetic acid

HRID 2110217
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HRID 2110217 반응식
[CH3:1][C:2]([CH3:29])([CH3:28])[CH2:3][C:4]([C:6]1[N:7]=[C:8]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[N:9]2[CH2:14][CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11][C:10]=12)=[O:5].[C:30]([OH:36])([C:32]([F:35])([F:34])[F:33])=[O:31]>C(Cl)Cl>[F:33][C:32]([F:35])([F:34])[C:30]([OH:36])=[O:31].[CH3:1][C:2]([CH3:29])([CH3:28])[CH2:3][C:4]([C:6]1[N:7]=[C:8]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[N:9]2[CH2:14][CH2:13][NH:12][CH2:11][C:10]=12)=[O:5].[C:30]([OH:36])([C:32]([F:35])([F:34])[F:33])=[O:31]
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참가 물질

5

반응물 2

HCID 6422Trifluoroacetic acidHCID 57635573tert-butyl 1-(3,3-dimethylbutanoyl)-3-phenyl-5,6-dihydro-imidazo[1,5-a]pyrazine-7(8H)-carboxylate

생성물 2

HCID 6422Trifluoroacetic acidHCID 669319443,3-Dimethyl-1-(3-phenyl-5,6,7,8-tetrahydroimidazo-[1,5-a]pyrazin-1-yl)butan-1-one 2,2,2-trifluoroacetate

시약·촉매·용매 1

HCID 6344Dichloromethane
용매

실험 절차

Intermediate 26B (0.08 g, 0.20 mmol) was dissolved in DCM and TFA was added. The resulting mixture was stirred for 2 hours. The mixture was concentrated, diluted with water and acetonitrile and lyophilized to produce the desired product as a TFA salt. The residue was dissolved in methanol and filtered through a SPE SCX tube column, eluting with 2N ammonia in methanol to provide Compound 291 (0.055 g, 90%) as a free base. 1H-NMR (400 MHz, CD3OD) δ: 1.05 (s, 9H), 2.87 (s, 2H), 3.15 (t, 2H), 4.07 (t, 2H), 4.35 (s, 2H), 7.52 (m, 3H), 7.67 9 m, 2H); LCMS (+ESI) m/z 298.1 [M+H]+.

후처리

  1. concentrationThe mixture was concentrated
  2. additiondiluted with water and acetonitrile

출처 및 근거

ORD 기록
ord-143202ae6b594f26a3c41d141f1433c4
출처 데이터셋
uspto-grants-2009_04
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07517874B2

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