Methylamine → HCID 68906846, 화합물

HRID 2110351노트

반응식

[ClH:1].FC1C=C2C(=CC=1)NC=C2[C@H:12]([C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([F:24])[CH:19]=1)[C@@H:13]([OH:17])[CH2:14][NH:15][CH3:16].[F:25][C:26]1[CH:27]=[C:28]2[C:32](=[CH:33][CH:34]=1)N([C@@H](C1C=CC=CC=1)[C@H](O)COS(C1C=CC(C)=CC=1)(=O)=O)C=[CH:29]2.[CH3:56][NH2:57]>>[ClH:1].[F:25][C:26]1[CH:27]=[C:28]2[C:32](=[CH:33][CH:34]=1)[N:57]([C@@H:12]([C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([F:24])[CH:19]=1)[C@H:13]([OH:17])[CH2:14][NH:15][CH3:16])[CH:56]=[CH:29]2

참가 물질

반응물 3

HCID 6329Methylamine

HCID 68907697HCID 68907697, 화합물

HCID 87617820HCID 87617820, 화합물

생성물 1

HCID 68906846HCID 68906846, 화합물

실험 절차

In an analogous manner to EXAMPLE 5, (1S,2R)-1-(5-fluoro-1H-indol-3-yl)-1-(3-fluorophenyl)-3-(methylamino)propan-2-ol hydrochloride was prepared from (2S,3S)-toluene-4-sulfonic acid 3-(5-fluoro-indol-1-yl)-2-hydroxy-3-phenyl-propyl ester and methylamine as a light tan solid. MS (ES) m/z 317.2; HRMS: calcd for C18H18F2N2O+H+, 317.14599; found (ESI, [M+H]+), 317.1472.

출처 및 근거

ORD 기록: ord-ecadaf3eb0354e5bba75ad4a282e6f9e
출처 데이터셋: uspto-grants-2009_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07517899B2

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