HCID 21874993, 화합물 → 5-Amino-3-bromo-2-pyridinecarbonitrile

HRID 2110478노트

반응식

HRID 2110478 반응식
[Br:1][C:2]1[C:3]([C:11]#[N:12])=[N:4][CH:5]=[C:6]([N+:8]([O-])=O)[CH:7]=1>[Fe].CCOCC>[NH2:8][C:6]1[CH:7]=[C:2]([Br:1])[C:3]([C:11]#[N:12])=[N:4][CH:5]=1

참가 물질

4

반응물 1

HCID 21874993HCID 21874993, 화합물

생성물 1

HCID 218752405-Amino-3-bromo-2-pyridinecarbonitrile

시약·촉매·용매 2

HCID 23925Iron촉매HCID 3283Diethyl Ether용매

실험 절차

3-Bromo-2-cyano-5-nitropyridine (0.4 g, 1.75 mmol) and iron powder (0.51 g, 8.8 mmol, 325 Mesh) were reacted as described in example 762D. The crude solid obtained by trituration with ether was purified by SiO2 Prep-TLC using 4:1 CH2Cl2/ether as eluent to give compound 769A (0.16 g, (65%) as an off-white solid. HPLC: 100% at 1.77 min(YMC S5 ODS column) eluting with 10-90% aqueous methanol containing 0.2% phosphoric acid over a 4 min gradient monitoring at 220 nm. MS (ES): m/z 197.93 [M+H]+.

후처리

  1. customwas purified by SiO2 Prep-TLC

출처 및 근거

ORD 기록
ord-1d4d47d5dcc2446092ad5f0085280875
출처 데이터셋
uspto-grants-2009_04
특허 번호
US07517904B2

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