Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Iodine → 4-Chloro-7-[1-(tert-butoxycarbonyl)-3-iodoindol-2-yl]isoindolinone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Iodine | HCID 807 | — |
| 반응물 | 4-Chloro-7-(1-(tert-butoxycarbonyl)indol-2-yl)isoindolinone | HCID 68487594 | — |
| 촉매 | HCID 178418844 | HCID 178418844 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 4-Chloro-7-[1-(tert-butoxycarbonyl)-3-iodoindol-2-yl]isoindolinone | HCID 68492204 | 36% |
반응 단계
In a similar manner to Step 1 of Example 161, 4-chloro-7-(1-(tert-butoxycarbonyl)-indol-2-yl)isoindolinone (374 mg, 0.980 mmol) was dissolved in ethanol (26 mL), and the solution was treated with iodine (299 mg, 1.18 mmol) and silver sulfate (306 mg, 0.980 mmol), followed by purification by slurry using hexane and diisopropylether to obtain 4-chloro-7-[1-(tert-butoxycarbonyl)-3-iodoindol-2-yl]isoindolinone (179 mg, yield 36%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07745641B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-e091ca1a6fd64562984b79a3781fd88c |
| 출처 메모 | uspto-grants-2010_06 |