5,8-Difluoro-2H-chromene → 8-Bromo-6-fluoro-2H-chromene

반응식

FC1C=CC(F)=C2C=1C=CCO2.[Br:13][C:14]1[CH:19]=[C:18]([F:20])[CH:17]=[CH:16][C:15]=1[O:21][CH2:22][C:23]#[CH:24]>>[Br:13][C:14]1[CH:19]=[C:18]([F:20])[CH:17]=[C:16]2[C:15]=1[O:21][CH2:22][CH:23]=[CH:24]2

참가 물질

반응물 2

HCID 224828145,8-Difluoro-2H-chromene

HCID 224828682-Bromo-4-fluoro-1-prop-2-ynyloxybenzene

생성물 1

HCID 224827988-Bromo-6-fluoro-2H-chromene수율 47%

실험 절차

This compound was prepared analogously to 5,8-difluoro-2H-chromene but using (15 g, 65 mmol) of 2-bromo-4-fluoro-1-prop-2-ynyloxybenzene to give the title compound (7 g, 46%)

출처 및 근거

ORD 기록: ord-6ece1586a9944e1c930fe705db6c11d5
출처 데이터셋: uspto-grants-2009_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07517992B2

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