6-Methoxy-1,2,3,4-tetrahydronaphthalen-1-ol → 7-Methoxy-1,2-dihydronaphthalene

HRID 2110979

반응식

HRID 2110979 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH:9](O)[CH2:8][CH2:7][CH2:6]2>C1(C)C=CC=CC=1>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10]([CH:9]=[CH:8][CH2:7][CH2:6]2)=[CH:11][CH:12]=1

참가 물질

3

반응물 1

HCID 110522116-Methoxy-1,2,3,4-tetrahydronaphthalen-1-ol

생성물 1

HCID 5947787-Methoxy-1,2-dihydronaphthalene수율 96%

시약·촉매·용매 1

HCID 1140Toluene용매

반응 조건

온도
115 °C

실험 절차

Crude 6-methoxy-1,2,3,4-tetrahydronaphthalen-1-ol (10.3 g, 0.058 mol) was dissolved in 100 ml of toluene and heated in an oil bath (115° C.). P-tolylsulphonic acid (20 mg) was added to the reaction mixture and it was refluxed for about 1 h. The reaction was monitored by GC. The reaction mixture was then cooled and washed with sat. NaHCO3 solution, water and brine and organic layer was dried over Na2SO4. Concentration gave 8.87 g of light brown oil. Yield 96%.

후처리

  1. temperaturewas refluxed for about 1 h
  2. temperatureThe reaction mixture was then cooled
  3. washwashed with sat. NaHCO3 solution, water and brine and organic layer
  4. dry with materialwas dried over Na2SO4
  5. concentrationConcentration

출처 및 근거

ORD 기록
ord-7c095eeee5fd44d19f6edf1be616582b
출처 데이터셋
uspto-grants-2009_04
특허 번호
US07517992B2

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