Acetic Acid → 6-(4-Chlorophenyl)-2,3-dihydropyridazin-3-one
반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH2:9][CH2:10][C:11](=[O:14])[NH:12][N:13]=2)=[CH:4][CH:3]=1.C(O)(=O)C.BrBr>O>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[CH:10][C:11](=[O:14])[NH:12][N:13]=2)=[CH:4][CH:3]=1참가 물질
5
실험 절차
To a solution of 6-(4-chlorophenyl)-4,5-dihydropyridazinone (11.75 g) and glacial acetic acid (100 ml) was added dropwise 3 ml of bromine and the mixture was heated at 60°-70° C. for 3 h. The resulting mixture was cooled and slowly poured into 400 ml of cold water. The resulting white solid was filtered and dried to yield 10.83 g (89%) of 6-(4-chlorophenyl)pyridazinone.
후처리
- temperaturethe mixture was heated at 60°-70° C. for 3 h
- temperatureThe resulting mixture was cooled
- filtrationThe resulting white solid was filtered
- customdried
출처 및 근거
- ORD 기록
- ord-9050fa6258a9415bb85240ff78c07174
- 출처 데이터셋
- uspto-grants-1998_03
- 특허 번호
- US05728698
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