Diethyl Ether → 1-[5-(3-Chlorophenyl)-2-furyl]ethan-1-ol

HRID 2111478

반응식

HRID 2111478 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[O:12][C:11]([CH:13]=[O:14])=[CH:10][CH:9]=2)[CH:5]=[CH:6][CH:7]=1.C[Mg+].[Br-].[CH3:18]COCC>C1COCC1>[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[O:12][C:11]([CH:13]([OH:14])[CH3:18])=[CH:10][CH:9]=2)[CH:5]=[CH:6][CH:7]=1

참가 물질

5

반응물 3

HCID 3283Diethyl EtherHCID 6098225-(3-Chlorophenyl)furfuralHCID 178418689HCID 178418689, 화합물

생성물 1

HCID 624985931-[5-(3-Chlorophenyl)-2-furyl]ethan-1-ol

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 5-(3-chlorophenyl)furan-2-carbaldehyde (1.0 equiv.) in THF at 0° C. was added MeMgBr in ether (3.0 equiv.) and stirred for 45 min. The reaction was quenched with water, diluted with ether and filtered through Celite. The organic layer was separated and washed with brine, dried over MgSO4, and concentrated to give the 1-[5-(3-chlorophenyl)-2-furyl]ethan-1-ol.

후처리

  1. customThe reaction was quenched with water
  2. additiondiluted with ether
  3. filtrationfiltered through Celite
  4. customThe organic layer was separated
  5. washwashed with brine
  6. dry with materialdried over MgSO4
  7. concentrationconcentrated

출처 및 근거

ORD 기록
ord-91b98511bff74a6a8e5fcf415860793e
출처 데이터셋
uspto-grants-2009_04
특허 번호
US07521062B2

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