Trifluoroacetic acid → 1-(3-Phenyl-1,2-oxazol-5-yl)methanamine
반응식
FC(F)(F)C(O)=O.C(OC([NH:15][CH2:16][C:17]1[O:21][N:20]=[C:19]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH:18]=1)=O)(C)(C)C>C(Cl)Cl>[NH2:15][CH2:16][C:17]1[O:21][N:20]=[C:19]([C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=2)[CH:18]=1참가 물질
4
실험 절차
Trifluoroacetic acid (1.7 ml, 2.6 mmol) was added dropwise to a solution of 5-(tert-butoxycarbonylaminomethyl)-3-phenylisoxazole (Method 43; 473 mg, 1.73 mmol) in DCM (8 ml) cooled in an ice bath. The mixture was warmed to ambient temperature and stirred for 18 hours and the volatiles removed by evaporation. The residue was triturated with ether to give the title compound (427 mg, 86%). NMR (DMSO) 4.33 (s, 2H), 7.1 (s, 1H), 7.5 (m, 3H), 7.8 (m, 2H), 8.6 (br s, 3H).
후처리
- temperaturecooled in an ice bath
- customthe volatiles removed by evaporation
- customThe residue was triturated with ether
출처 및 근거
- ORD 기록
- ord-ca4fd63d70514e33a8f4947a3b8d19a2
- 출처 데이터셋
- uspto-grants-2009_04
- 특허 번호
- US07521453B2
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