Sodium Azide → 3-(Azidomethyl)-5-methyl-1,2-oxazole

HRID 2111679노트

반응식

HRID 2111679 반응식
Cl[CH2:2][C:3]1[CH:7]=[C:6]([CH3:8])[O:5][N:4]=1.[N-:9]=[N+:10]=[N-:11].[Na+]>CN(C=O)C.O>[N:9]([CH2:2][C:3]1[CH:7]=[C:6]([CH3:8])[O:5][N:4]=1)=[N+:10]=[N-:11]

참가 물질

5

반응물 2

HCID 33557Sodium AzideHCID 27357633-(Chloromethyl)-5-methyl-1,2-oxazole

생성물 1

HCID 234409373-(Azidomethyl)-5-methyl-1,2-oxazole수율 73.7%

시약·촉매·용매 2

HCID 962Water용매HCID 6228Dimethylformamide용매

실험 절차

3-Chloromethyl-5-methylisoxazole (500 mg, 3.8 mmol) and sodium azide (494 mg, 7.6 mmol) were heated in DMF (10 ml) at 60° C. for 6 hours. The reaction mixture was diluted with water then extracted with EtOAc. The organic extracts were dried (MgSO4) and the volatiles removed by evaporation to give the title compound (387 mg, 73%) as an oil. NMR (DMSO): 2.40 (s, 3H), 4.48 (s, 2H), 6.28 (s, 1H).

후처리

  1. extractionthen extracted with EtOAc
  2. dry with materialThe organic extracts were dried (MgSO4)
  3. customthe volatiles removed by evaporation

출처 및 근거

ORD 기록
ord-54ceae5d828b4fef9058789fa5954f32
출처 데이터셋
uspto-grants-2009_04
특허 번호
US07521453B2

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