Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 2111999생성일: 2026년 10월 26일
Potassium Carbonate → methyl 2-[(4-{2-[4-(1H-imidazol-1-yl)phenoxy]ethyl}phenoxy)methyl]benzoate
https://huagongshe.com/reaction/2111999
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 1-(p-Hydroxyphenyl)imidazole | HCID 82315 | — |
| 반응물 | Methyl 2-[(4-{2-[(methylsulfonyl)oxy]ethyl}phenoxy)methyl]benzoate | HCID 86601923 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | methyl 2-[(4-{2-[4-(1H-imidazol-1-yl)phenoxy]ethyl}phenoxy)methyl]benzoate | HCID 68869830 | 113.7% |
반응 단계
Methyl 2-[(4-{2-[(methylsulfonyl)oxy]ethyl}phenoxy)methyl]benzoate (0.2 g, 0.55 mmol) and 4-(1H-imidazol-1-yl)phenol (0.11 g, 0.66 mmol) was dissolved in acetonitrile (10 ml) and potassium carbonate (0.09 g, 0.66 mmol) was added. The mixture was stirred over night at 75° C. Remove the acetonitrile by evaporation, dilute with EtOAc (10 ml) and wash the organic phase with Brine three times, dry (MgSO4) and evaporate. This gave 0.268 g of methyl 2-[(4-{2-[4-(1H-imidazol-1-yl)phenoxy]ethyl}phenoxy)methyl]benzoate (yield 90%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US07521461B2 |
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| 출처 데이터셋 | uspto-grants-2009_04 |
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| ORD ID | ord-eabb4deeb9264e45adee50c353f77ca3 |
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| 출처 메모 | uspto-grants-2009_04 |
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