Water → HCID 178487895, 화합물

HRID 2112101노트

반응식

HRID 2112101 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:12]2[NH:13][CH:14]=[C:15]([CH2:17][C:18](O)=[O:19])[N:16]=2)[CH:6]=[CH:7][C:8]=1[N+:9]([O-:11])=[O:10].O>C1COCC1>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:12]2[NH:13][CH:14]=[C:15]([CH2:17][CH2:18][OH:19])[N:16]=2)[CH:6]=[CH:7][C:8]=1[N+:9]([O-:11])=[O:10]

참가 물질

4

반응물 2

HCID 962WaterHCID 178487908HCID 178487908, 화합물

생성물 1

HCID 178487895HCID 178487895, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

반응 조건

온도
0 °C

실험 절차

1.45 g (5.23 mmol) [2-(3-methoxy-4-nitro-phenyl)-1H-imidazol-4-yl]-acetic acid are dissolved in 36 ml THF and cooled to 0° C. and combined with 10 ml (18 mmol) borane-THF complex (1.8 mol/V). After 1 h the mixture is heated to 20° C. and stirred for 16 h. Water is added until the development of gas has ended. Then the mixture is extracted twice with saturated aqueous sodium hydrogen carbonate solution and ethyl acetate. The organic phases are combined, dried and freed from the solvent in vacuo.

후처리

  1. temperatureAfter 1 h the mixture is heated to 20° C.
  2. extractionThen the mixture is extracted twice with saturated aqueous sodium hydrogen carbonate solution and ethyl acetate
  3. customdried

출처 및 근거

ORD 기록
ord-756862ec6c424e9dab147694a5d8f477
출처 데이터셋
uspto-grants-2009_04
특허 번호
US07521457B2

반응 노트

불러오는 중…