3,3-Dimethyl-7-nitro-2,3-dihydro-isoindol-1-one → 3,3-Dimethyl-7-amino-2,3-dihydro-isoindol-1-one
반응식
[CH3:1][C:2]1([CH3:15])[C:10]2[C:5](=[C:6]([N+:11]([O-])=O)[CH:7]=[CH:8][CH:9]=2)[C:4](=[O:14])[NH:3]1>CO.[Pd]>[CH3:1][C:2]1([CH3:15])[C:10]2[C:5](=[C:6]([NH2:11])[CH:7]=[CH:8][CH:9]=2)[C:4](=[O:14])[NH:3]1참가 물질
4
실험 절차
67 mg (0.325 mmol) 3,3-dimethyl-7-nitro-2,3-dihydro-isoindol-1-one are dissolved in 50 ml of methanol and combined with 10 mg palladium on charcoal. The mixture is hydrogenated for 16 h at 4 bar H2 pressure and ambient temperature. Then the catalyst is filtered off and the solvent is eliminated in vacuo.
후처리
- filtrationThen the catalyst is filtered off
출처 및 근거
- ORD 기록
- ord-5abc06f3a19d4a38a44e89590cf20fc1
- 출처 데이터셋
- uspto-grants-2009_04
- 특허 번호
- US07521457B2
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