7-Dibenzylamino-2-(2-fluoro-ethyl)-3,3-dimethyl-2,3-dihydro-isoindol-1-one → 7-Amino-2-(2-fluoro-ethyl)-3,3-dimethyl-2,3-dihydro-isoindol-1-one

HRID 2112110노트

반응식

HRID 2112110 반응식
C([N:8](CC1C=CC=CC=1)[C:9]1[CH:10]=[CH:11][CH:12]=[C:13]2[C:17]=1[C:16](=[O:18])[N:15]([CH2:19][CH2:20][F:21])[C:14]2([CH3:23])[CH3:22])C1C=CC=CC=1>CO.[Pd]>[NH2:8][C:9]1[CH:10]=[CH:11][CH:12]=[C:13]2[C:17]=1[C:16](=[O:18])[N:15]([CH2:19][CH2:20][F:21])[C:14]2([CH3:23])[CH3:22]

참가 물질

4

반응물 1

HCID 866061867-Dibenzylamino-2-(2-fluoro-ethyl)-3,3-dimethyl-2,3-dihydro-isoindol-1-one

생성물 1

HCID 576401547-Amino-2-(2-fluoro-ethyl)-3,3-dimethyl-2,3-dihydro-isoindol-1-one

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

75 mg (0.188 mmol) 7-dibenzylamino-2-(2-fluoro-ethyl)-3,3-dimethyl-2,3-dihydro-isoindol-1-one are dissolved in 50 ml of methanol and combined with 10 mg palladium on charcoal. The mixture is hydrogenated for 16 h at 5 bar H2 pressure and ambient temperature. Then the catalyst is filtered off and the solvent is eliminated in vacuo.

후처리

  1. filtrationThen the catalyst is filtered off

출처 및 근거

ORD 기록
ord-a2c4dccc7c114ef3a319530cc007410d
출처 데이터셋
uspto-grants-2009_04
특허 번호
US07521457B2

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