1-Ethylpiperazine → 4-(4-Ethyl-1-piperazinyl)-1-(benzenesulfonyl)-1H-indole

반응식

Br[C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[CH:5][N:6]2[S:11]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)(=[O:13])=[O:12].[CH2:20]([N:22]1[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1)[CH3:21]>>[CH2:20]([N:22]1[CH2:27][CH2:26][N:25]([C:2]2[CH:10]=[CH:9][CH:8]=[C:7]3[C:3]=2[CH:4]=[CH:5][N:6]3[S:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)(=[O:13])=[O:12])[CH2:24][CH2:23]1)[CH3:21]

참가 물질

반응물 2

HCID 791961-Ethylpiperazine

HCID 220153114-Bromo-1-(phenylsulfonyl)-1H-indole

생성물 1

HCID 101359844-(4-Ethyl-1-piperazinyl)-1-(benzenesulfonyl)-1H-indole

실험 절차

The title compound was prepared from 4-bromo-1-(benzenesulfonyl)-1H-indole and 4-ethylpiperazine according to Method 1 to afford 129 mg (48%) of a white solid: 1H NMR (CD3OD) δ 7.94-6.81 (m, 10H), 3.69-3.62 (m, 4H), 2.34-3.26 (partly hidden) (m, 4H), 3.14-3.04 (m, 2H), 1.40 (t, J=7 Hz, 3H); MS (ESI) 370.1 (M+H)+; Purity (HPLC) >95%.

출처 및 근거

ORD 기록: ord-a4b3f56385e64166b5625c96aa9864c7
출처 데이터셋: uspto-grants-2009_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07524839B2

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