2-Chlorobenzaldehyde → (2-Amino-4-fluoro-5-methoxyphenyl)-(2-chlorophenyl)-methanone

반응식

[Cl:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]=[O:5].[F:10][C:11]1[CH:12]=[C:13]([CH:15]=[CH:16][C:17]=1[O:18][CH3:19])[NH2:14]>>[NH2:14][C:13]1[CH:12]=[C:11]([F:10])[C:17]([O:18][CH3:19])=[CH:16][C:15]=1[C:4]([C:3]1[CH:6]=[CH:7][CH:8]=[CH:9][C:2]=1[Cl:1])=[O:5]

참가 물질

반응물 2

HCID 69962-Chlorobenzaldehyde

HCID 5811103-Fluoro-4-methoxyaniline

생성물 1

HCID 57642329(2-Amino-4-fluoro-5-methoxyphenyl)-(2-chlorophenyl)-methanone

실험 절차

(2-amino-4-fluoro-5-methoxyphenyl)-(2-chlorophenyl)-methanone (Xdd) was prepared by reacting 2-chlorobenzaldehyde with 0.0223 moles of 3-fluoro-4-methoxy aniline in a manner analogous to Example 1. MH+/Z=280.

출처 및 근거

ORD 기록: ord-885661ad39264b7bbb572e6fd6ab4bc2
출처 데이터셋: uspto-grants-2009_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07524840B2

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