Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Chlorosuccinimide → 3-Chloro-1H-indole-5-carboxylic acid methyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Chlorosuccinimide | HCID 31398 | — |
| 반응물 | methyl 1H-indole-5-carboxylate | HCID 2737635 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 3-Chloro-1H-indole-5-carboxylic acid methyl ester | HCID 21998728 | 62.6% |
반응 단계
A mixture of 1.4 g (8 mmol) 1H-indole-5-carboxylic acid methyl ester and 1.28 g (9.6 mmol) N-chlorosuccinimid in 40 mL methanol was stirred at room temperature for 16 h. The mixture was evaporated to dryness and taken up in DCM washed with 1N NaHCO3 aq, dried with MgSO4, filtered and evaporated to dryness to yield 1.05 g (62%) of the title compound. MS(m/e): 210.1 (MH+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07432255B2 |
| 출처 데이터셋 | uspto-grants-2008_10 |
| ORD ID | ord-3b5c17169e574e9a83ea3a80bfdc003e |
| 출처 메모 | uspto-grants-2008_10 |