2-Chloro-4-phenylpyridine → 2-{4-[4-(2-Fluorophenyl)piperazin-1-yl]butyl}amino-4-phenylpyridine
반응식
Cl[C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:5]=[CH:4][N:3]=1.[F:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[N:21]1[CH2:26][CH2:25][N:24]([CH2:27][CH2:28][CH2:29][CH2:30][NH2:31])[CH2:23][CH2:22]1>>[F:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[N:21]1[CH2:22][CH2:23][N:24]([CH2:27][CH2:28][CH2:29][CH2:30][NH:31][C:2]2[CH:7]=[C:6]([C:8]3[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=3)[CH:5]=[CH:4][N:3]=2)[CH2:25][CH2:26]1참가 물질
3
실험 절차
{2-{4-[4-(2-Fluorophenyl)piperazin-1-yl]butyl}amino-4-phenylpyridine is prepared by reacting 2-chloro-4-phenylpyridine (preparation described in EP 036 638) and 4-[4-(2-fluorophenyl)piperazin-1-yl]butylamine (Example 1, step b) using the same method as described in Example 1, step d.
출처 및 근거
- ORD 기록
- ord-ce886a610a2148c49259d3a5c8f3ea06
- 출처 데이터셋
- uspto-grants-2008_10