Thionyl Chloride → 2-Chloro-4-(chloromethyl)-6-methylpyridine

HRID 2113634노트

반응식

HRID 2113634 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([CH2:8]O)[CH:5]=[C:4]([CH3:10])[N:3]=1.S(Cl)([Cl:13])=O>C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:7]=[C:6]([CH2:8][Cl:13])[CH:5]=[C:4]([CH3:10])[N:3]=1

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 22504306(2-Chloro-6-methylpyridin-4-yl)methanol

생성물 1

HCID 216981672-Chloro-4-(chloromethyl)-6-methylpyridine

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

2.2 1.14 g of (2-chloro-6-methylpyridin-4-yl)methanol are initially introduced in 50 ml of toluene, and 1.05 ml of thionyl chloride are slowly added dropwise with ice cooling. The mixture is boiled under reflux overnight. After cooling, the solvent is removed, giving 2-chloro-4-chloromethyl-6-methylpyridine as brown oil (1.1 g).

후처리

  1. temperatureunder reflux overnight
  2. temperatureAfter cooling
  3. customthe solvent is removed

출처 및 근거

ORD 기록
ord-e624334278f045eebad3125f2b59d0fb
출처 데이터셋
uspto-grants-2008_10
특허 번호
US07432282B2

반응 노트

불러오는 중…