3-Pyridinemethanamine → 3-Chloro-4-phenyl-1-[(pyridin-3-yl)methyl]-1H-pyrrole-2,5-dione

HRID 2113741노트

반응식

HRID 2113741 반응식
[Cl:1][C:2]1[C:3](=[O:14])O[C:5](=[O:13])[C:6]=1[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.[NH2:15][CH2:16][C:17]1[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=1>C(O)(=O)C>[Cl:1][C:2]1[C:3](=[O:14])[N:15]([CH2:16][C:17]2[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=2)[C:5](=[O:13])[C:6]=1[C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=1

참가 물질

4

반응물 2

HCID 310183-PyridinemethanamineHCID 234471953-Chloro-4-phenylfuran-2,5-dione

생성물 1

HCID 691451723-Chloro-4-phenyl-1-[(pyridin-3-yl)methyl]-1H-pyrrole-2,5-dione

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

A solution of 3-chloro-4-phenylfuran-2,5-dione (1.00 mmol, 209 mg) and 3-(aminomethyl)-pyridine (1.00 mmol, 26 mg) in glacial acetic acid (4 mL) was heated in a microwave reactor at 120° C. for two min. After cooling, the solvent was evaporated at reduced pressure. The crude product was used without purification.

후처리

  1. temperatureAfter cooling
  2. customthe solvent was evaporated at reduced pressure
  3. customThe crude product was used without purification

출처 및 근거

ORD 기록
ord-015f37b0aa2a452dbb71214733c18070
출처 데이터셋
uspto-grants-2008_10
특허 번호
US07432288B2

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