Cyclobutanecarboxylic acid → HCID 44532791, 화합물
반응식
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:21])=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([NH:16][CH2:17][CH:18]3[CH2:20][CH2:19]3)=[O:15])=[CH:10][CH:9]=2)[CH:7]=1.[CH:22]1([C:26](O)=[O:27])[CH2:25][CH2:24][CH2:23]1>>[CH:18]1([CH2:17][NH:16][C:14]([C:11]2[CH:12]=[CH:13][C:8]([C:6]3[C:5]([CH3:21])=[CH:4][CH:3]=[C:2]([NH:1][C:26]([CH:22]4[CH2:25][CH2:24][CH2:23]4)=[O:27])[CH:7]=3)=[CH:9][CH:10]=2)=[O:15])[CH2:20][CH2:19]1참가 물질
3
실험 절차
N-(4′-{[(Cyclopropylmethyl)amino]carbonyl}-6-methyl-1,1′-biphenyl-3-yl)cyclobutanecarboxamide was prepared from 5′-amino-N-(cyclopropylmethyl)-2′-methyl-1,1′-biphenyl-4-carboxamide and cyclobutanecarboxylic acid using method D. NMR; δH [2H6]—DMSO 9.71,(1H, s), 8.61,(1H, t), 7.91,(2H, d), 7.52-7.49,(2H, m), 7.40,(2H, d), 7.21,(1H, d), 3.21-3.14,(3H, m), 2.24-2.15,(5H, m), 2.07,(2H, m), 1.91, (1H, m), 1.78,(1H, m), 1.04,(1H, m), 0.43,(2H, m), 0.24,(2H, m). LCMS: retention time 3.30 min, MH+363.
출처 및 근거
- ORD 기록
- ord-44aa22d0dba8481f8e7e77403a3421a6
- 출처 데이터셋
- uspto-grants-2008_10