1,2-Oxazole-5-carboxylic acid → HCID 44578461, 화합물
반응식
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:21])=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([NH:16][CH2:17][CH:18]3[CH2:20][CH2:19]3)=[O:15])=[CH:10][CH:9]=2)[CH:7]=1.[O:22]1[C:26]([C:27](O)=[O:28])=[CH:25][CH:24]=[N:23]1>>[CH:18]1([CH2:17][NH:16][C:14]([C:11]2[CH:12]=[CH:13][C:8]([C:6]3[C:5]([CH3:21])=[CH:4][CH:3]=[C:2]([NH:1][C:27]([C:26]4[O:22][N:23]=[CH:24][CH:25]=4)=[O:28])[CH:7]=3)=[CH:9][CH:10]=2)=[O:15])[CH2:20][CH2:19]1참가 물질
3
실험 절차
N-(4′-{[(Cyclopropylmethyl)amino]carbonyl}-6-methyl-1,1′-biphenyl-3-yl)isoxazole-5-carboxamide was prepared from 5′-amino-N-(cyclopropylmethyl)-2′-methyl-1,1′-biphenyl-4- carboxamide and isoxazole-5-carboxylic acid using method D. NMR; δH [2H6] —DMSO 10.75, (1H, s), 8.81,(1H, d), 8.62,(1H, t), 7.93,(2H, d), 7.70,(1H, dd), 7.66,(1H, d), 7.44,(2H, d), 7.32,(1H, d), 7.24,(1H, d), 3.16,(2H, t), 2.21,(3H, s), 1.04,(1H, m), 0.43,(2H, m), 0.24,(2H, m). LCMS: retention time 3.17 min, MH+376.
출처 및 근거
- ORD 기록
- ord-5f034c0eb59244139f5cd29628198f73
- 출처 데이터셋
- uspto-grants-2008_10