1-tert-Butoxycarbonyl-3-methoxycarbonyl-5-nitropyrazole → 5-Amino-1-tert-butoxycarbonyl-3-methoxycarbonylpyrazole

HRID 2114271노트

반응식

HRID 2114271 반응식
[C:1]([O:5][C:6]([N:8]1[C:12]([N+:13]([O-])=O)=[CH:11][C:10]([C:16]([O:18][CH3:19])=[O:17])=[N:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[H][H]>[Pd]>[NH2:13][C:12]1[N:8]([C:6]([O:5][C:1]([CH3:2])([CH3:3])[CH3:4])=[O:7])[N:9]=[C:10]([C:16]([O:18][CH3:19])=[O:17])[CH:11]=1

참가 물질

4

반응물 2

HCID 597735771-tert-Butoxycarbonyl-3-methoxycarbonyl-5-nitropyrazoleHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 597733355-Amino-1-tert-butoxycarbonyl-3-methoxycarbonylpyrazole

시약·촉매·용매 1

HCID 23938Palladium촉매

실험 절차

A mixture of 1.0 eq. of 19 and 0.1 wt/wt eq. of 10% Pd on carbon was hydrogenated at 10-60 psi of hydrogen for a time sufficient for reaction completion. The reaction mixture was filtered through Celite. The filtrate was concentrated by rotary evaporation. The crude material was dried under vacuum to give product 20.

후처리

  1. filtrationThe reaction mixture was filtered through Celite
  2. concentrationThe filtrate was concentrated by rotary evaporation
  3. dry with materialThe crude material was dried under vacuum

출처 및 근거

ORD 기록
ord-6ce485c14eb14fb0a5b5ade4c8ec95d2
출처 데이터셋
uspto-grants-2008_10
특허 번호
US07432379B2

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