Pyrazole → (r)-4-Bromo-5-(2-chlorobenzoylamino)-1-methyl-pyrazole-3-carboxylic acid (1,5-dimethyl-2-oxo-2,3,4,5-tetrahydro-1h-benzo[b][1,4]diazepin-3-yl)amide

HRID 2114308노트

반응식

HRID 2114308 반응식
N1C=C[CH:3]=N1.[CH3:6][N:7]([C@@H:26]([C:28]1C=CC=C[CH:29]=1)C)[C:8](C1C(Br)=C(NC(=O)C2C=CC=CC=2Cl)NN=1)=[O:9].[Cl:34][C:35]1[CH:43]=[CH:42][CH:41]=[CH:40][C:36]=1[C:37](Cl)=[O:38].[N:44]1([CH2:49][CH2:50][NH:51][C:52]([C:54]2[C:58]([Br:59])=[C:57]([NH:60]C(=O)C3C=CC=CC=3Cl)[NH:56][N:55]=2)=[O:53])[CH2:48][CH2:47][CH2:46][CH2:45]1>>[CH3:6][N:7]1[C:8](=[O:9])[C@H:50]([NH:51][C:52]([C:54]2[C:58]([Br:59])=[C:57]([NH:60][C:37](=[O:38])[C:36]3[CH:40]=[CH:41][CH:42]=[CH:43][C:35]=3[Cl:34])[N:56]([CH3:3])[N:55]=2)=[O:53])[CH2:49][N:44]([CH3:45])[C:48]2[CH:47]=[CH:46][CH:29]=[CH:28][C:26]1=2

참가 물질

5

반응물 4

HCID 1048PyrazoleHCID 691102-Chlorobenzoyl chlorideHCID 178461679HCID 178461679, 화합물HCID 178522629HCID 178522629, 화합물

생성물 1

HCID 59773391(r)-4-Bromo-5-(2-chlorobenzoylamino)-1-methyl-pyrazole-3-carboxylic acid (1,5-dimethyl-2-oxo-2,3,4,5-tetrahydro-1h-benzo[b][1,4]diazepin-3-yl)amide

실험 절차

The pyrazole acid, prepared by coupling methyl ester 85 (Gen. Proc. 26) with 2-chlorobenzoyl chloride (21) followed by hydrolysis and bromination as shown in Gen. Proc. 8. was coupled to compound 92 (Procedure 27) using the method of Procedure 3.

후처리

  1. customfollowed by hydrolysis and bromination

출처 및 근거

ORD 기록
ord-f916f3bd86ef43c9848028e3ab5e0dd9
출처 데이터셋
uspto-grants-2008_10
특허 번호
US07432379B2

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