Pyrazole → 4-Bromo-5-(2-chloro-benzoylamino)-1-methyl-pyrazole-3-carboxylic acid {2-[4-(4,5-dihydro-1h-imidazol-2-yl)-phenyl]ethyl}amide
반응식
[NH:1]1[CH:5]=[CH:4]C=N1.[CH3:6][N:7]([C@@H](C1C=CC=CC=1)C)[C:8]([C:10]1[C:14]([Br:15])=[C:13]([NH:16][C:17](=[O:25])[C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[Cl:24])[NH:12][N:11]=1)=[O:9].Cl[C:35]1C=CC=CC=1C(Cl)=O.NC[CH2:46][C:47]1[CH:54]=[CH:53][C:50]([C:51]#[N:52])=[CH:49][CH:48]=1>>[NH:1]1[CH2:5][CH2:4][N:52]=[C:51]1[C:50]1[CH:49]=[CH:48][C:47]([CH2:46][CH2:6][NH:7][C:8]([C:10]2[C:14]([Br:15])=[C:13]([NH:16][C:17](=[O:25])[C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[Cl:24])[N:12]([CH3:35])[N:11]=2)=[O:9])=[CH:54][CH:53]=1참가 물질
5
실험 절차
The pyrazole acid, prepared by coupling methyl ester 85 (Procedure 26) with 2-chlorobenzoyl chloride (21) followed by hydrolysis and bromination as shown in Procedure 8, was coupled to amine 169 (Procedure 34) using the method of Procedure 10. Formation of the amidine using the method of Procedure 33.
후처리
- customfollowed by hydrolysis and bromination
출처 및 근거
- ORD 기록
- ord-e69be65630d14143b64dcbb7b8392af9
- 출처 데이터셋
- uspto-grants-2008_10
- 특허 번호
- US07432379B2
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